“So, for me, it was kind of liberating that once you’re in ketosis you’re not that hungry. And then, in the context of elevated ketones, they’re sort of anti-catabolic, and I talked about that a little bit. And, it liberated me from food. But when I… I like to enjoy food; I think food should be- I don’t think we should deprive ourselves of food. So, depriving myself of carbohydrates, that’s not something that I miss. So, and if people really miss that and enjoy that, I don’t think they should eliminate it from their menu or their meals. I think we need to enjoy food, that’s part of the process. But I enjoy food much more if I’m a little bit hungry. I appreciate the food, I enjoy it. Ketogenic food is like indulgent to me because for years that’s the stuff I avoided. So, I’m more happy with my food now than I ever was, I think. And I don’t have irrational food behavior.” – Dominic D’Agostino
Dominic D’Agostino, Ph.D., is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a senior research scientist at the Institute for Human and Machine Cognition.
With a diverse background in neuroscience, pharmacology, nutrition and physiology, Dom brings a unique perspective to the ketogenic diet. He believes it can be applied not just in treating medical conditions but also in contributing to overall health and optimizing human performance.
The findings from his research on nutritional ketosis have been utilized by Navy SEALs and NASA, and he recently has been at the forefront of research involving the use of nutritional ketosis as a tool to treat cancer.
I had the opportunity to sit down with Dom at the 2019 CrossFit Health Conference in Madison, where he presented on the emerging applications of ketosis. We talked about the basics of the ketogenic diet, how it can fit into the everyday person’s lifestyle, and the exciting research he’s conducting to learn more about using metabolic therapies in the treatment of cancer.
In this episode we discuss:
- What brought Dom to the CrossFit Health Conference
- His background and what influenced him to become a research scientist
- What led him to study nutritional ketosis
- A broad overview of the ketogenic diet
- Whether it’s necessary to actually measure ketones
- The physiological impacts of being in a state of ketosis
- The known and emerging applications of nutritional ketosis
- Whether there is an advantage to being in a state of ketosis versus simply eating low carb
- Populations for whom keto might not be a good fit
- Why keto can appear to affect men and women differently
- How ketosis can fit into a typical CrossFitter’s lifestyle and a competitor’s lifestyle
- What we know about ketosis and the microbiome
- The metabolic theory of cancer and why ketosis may be a tool for treatment
- How press-pulse therapy can be used as a metabolic management tool in the treatment of cancer
- What drives Dom to do self-experimentation and what he’s learned from it
- Three things Dom does on a regular basis that have the biggest positive impact on his health
- One thing he struggles to implement that could have a big impact on his health
- What a healthy life looks like to Dom
- Emerging Applications of Nutritional Ketosis, Dom D’Agostino at CrossFit Health
- Dominic D’Agostino – KetoNutrition: From Science to Application
- The Shocking Truth About the Keto Diet – Dom D’Agostino
- Ketogenic Diet Explained – The TRUTH with Dom D’Agostino
- Rutgers Department of Nutritional Sciences
- Rutgers School of Arts and Sciences – Biology
- Metabolic Therapy for Age-Dependent Impaired Wound Healing, Dr. Shannon Kesl
- Wound Healing Society
- Virta Health
- Rethinking Nutrition for Type-1 Diabetics, Andrew Koutnik
- A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome
- Robb Wolf
- Terry Wahls
- Zoë Harcombe
- Supersoldiers and enhanced cognitive function with ketones! A conversation with Dominic D’Agostino, PhD
- The Warburg Effect: How Does it Benefit Cancer Cells?
- Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
- Cancer as a metabolic disease: implications for novel therapeutics
- Press-pulse: a novel therapeutic strategy for the metabolic management of cancer
- Waking Up with Sam Harris
- The Five-Minute Journal
- Ep 78 – Lifestyle and Brain Health with Dr. David Perlmutter
- Ep 80 – Greg Glassman on Networking CrossFit Physicians and Fighting Chronic Disease
- Ep 97 – Challenging Conventional Cancer Care with Dr. Thomas Seyfried
- Ep 112 – Eating for Longevity with Dr. Valter Longo
If you like this episode, please subscribe to Pursuing Health on iTunes and give it a rating. I’d love to hear your feedback in the comments below and on social media using the hashtag #PursuingHealth. I look forward to bringing you future episodes with inspiring individuals and ideas about health every other Tuesday.
Disclaimer: This podcast is meant to share the experiences of various individuals. It does not provide medical advice, and it is not a substitute for advice from your physician or health care professional.